产品货号：
Z20798
中文名称：
Mouse SMARCA4抗体
英文名称：
Anti-Mouse SMARCA4 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Mouse SMARCA4 Antibody (C-term) |
| 指标别名 | ATP dependent helicase SMARCA4;BAF190;BAF190A;BRG1;BRG1 associated factor 190A;hSNF2b;Protein brahma homolog 1;Protein BRG 1;SMARCA4;SMARCA4/BRG1;SNF2;SNF2 BETA;SNF2B;SNF2L4;SNF2LB;SWI2;Transcription activator BRG1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB |
| 基因名称 | Smarca4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Mouse Smarca4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1352-1386 amino acids from the C-terminal region of mouse Smarca4. |
| 计算分子量 | 181kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Component of the CREST-BRG1 complex,a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex.In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex.Upon calcium influx,RB1 is dephosphorylated by calcineurin,which leads to release of the repressor complex.At the same time,there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism,which leads to transcriptional activation.The CREST-BRG1 complex also binds to the NR2B promoter,and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity).Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons,npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals,while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues.Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1 (By similarity). |
| Uniprot ID | Q3TKT4 |
相关搜索：Mouse SMARCA4抗体，Mouse SMARCA4(C-term)多抗，Anti-Mouse SMARCA4 Antibody (C-term)